Welcome to Talia Neal-Walthall
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Welcome to Talia Neal-Walthall

We are pleased to welcome Talia Neal-Walthall to ECETOC as a secondee. Talia joins us to work on topics related to exposure, an area central to much of our current scientific programme. She will be wi...
September 2026 news from the Sec Gen
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September 2026 news from the Sec Gen

Dear members and colleagues,As we move through the year, there is a good deal to share. This has been a busy period for ECETOC, with changes to our team, our governance, and the work ahead. Let me...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
TRA Task Force – Worker branch

TRA Task Force – Worker branch

Why? The Worker TRA Task Force has been active since 2019, delivering projects that advance the scientific basis of the Worker Targeted Risk Assessment (TRA) tool. Its overarching objective is to e...
Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Why?Regulatory assessment of immunotoxic properties of chemicals is a complex and challenging task​ Limited regulatory guidance exists​ Lack of industry and regulatory knowledge​...
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why?Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....

NGRA and NAMsRegulatory validation

Publications

Task Forces

Staged assessment: Exemplify the staged assessment process by using it to provide more information in low tonnage bands

Staged assessment: Exemplify the staged assessment process by using it to provide more information in low tonnage bands

Why? The current paradigm for identifying data (study) requirements is based upon a surrogate of exposure, namely production volume, which may under or overestimate real exposure. As presented in ...
Smart studies: Examine how in vivo studies could provide more information encompassing novel studies (and endpoints)

Smart studies: Examine how in vivo studies could provide more information encompassing novel studies (and endpoints)

Why? “Smart” or extended studies can be defined as in vivo studies that employ additional or different endpoints from conventional studies.They fall into 2 categories:those that follo...
Use of clinical data in identification of respiratory sensitisers

Use of clinical data in identification of respiratory sensitisers

Background There has been a propensity by regulators to rely primarily on health surveillance/clinical case study data (case reports, clinical databases, worker exposure studies) to classify substa...
Dose Selection Task Force

Dose Selection Task Force

Background Recent opinions published by the RAC on low top dose selection in animal toxicity studies have indicated an apparent intent of increasing dosages systematically in view of the criteria u...